Gerinnungssystem/en - Versionsgeschichte

Ischler: Die Seite wurde neu angelegt: „https://en.wikipedia.org/wiki/Coagulation“

2022-02-22T11:43:12Z

Die Seite wurde neu angelegt: „https://en.wikipedia.org/wiki/Coagulation“

Ischler: Die Seite wurde neu angelegt: „More information:“

2022-02-22T11:43:01Z

Die Seite wurde neu angelegt: „More information:“

Ischler: Die Seite wurde neu angelegt: „The coagulation cascade looks graphically as follows:“

2022-02-22T11:42:21Z

Die Seite wurde neu angelegt: „The coagulation cascade looks graphically as follows:“

Ischler: Die Seite wurde neu angelegt: „Thus, on the exogenous pathway, activation occurs very rapidly (within seconds), whereas on the endogenous pathway, the activation process proceeds via a large…“

2022-02-22T11:42:10Z

Die Seite wurde neu angelegt: „Thus, on the exogenous pathway, activation occurs very rapidly (within seconds), whereas on the endogenous pathway, the activation process proceeds via a large…“

Ischler: Die Seite wurde neu angelegt: „=== Coagulation cascade === Like primary hemostasis, the actual coagulation process is triggered by vascular and tissue injury and activated by two different p…“

2022-02-22T11:41:37Z

Die Seite wurde neu angelegt: „=== Coagulation cascade === Like primary hemostasis, the actual coagulation process is triggered by vascular and tissue injury and activated by two different p…“

Ischler am 22. Februar 2022 um 11:41 Uhr

2022-02-22T11:41:16Z

Ischler am 22. Februar 2022 um 11:40 Uhr

2022-02-22T11:40:22Z

Ischler am 22. Februar 2022 um 11:40 Uhr

2022-02-22T11:40:00Z

Ischler am 22. Februar 2022 um 11:39 Uhr

2022-02-22T11:39:12Z

Ischler am 22. Februar 2022 um 11:38 Uhr

2022-02-22T11:38:46Z

← Nächstältere Version		Version vom 22. Februar 2022, 11:43 Uhr
Zeile 38:		Zeile 38:
	More information:		More information:

−	https://de.wikipedia.org/wiki/~~Hämostase~~	+	https://en.wikipedia.org/wiki/Coagulation

@@ Zeile 36: / Zeile 36: @@
 [[Datei:Gerinnungskaskade_neu.png]]
-Weitere Informationen:
+More information:
 https://de.wikipedia.org/wiki/Hämostase

@@ Zeile 32: / Zeile 32: @@
 Thus, on the exogenous pathway, activation occurs very rapidly (within seconds), whereas on the endogenous pathway, the activation process proceeds via a larger number of intermediate steps and requires a longer time (minutes). In the normal coagulation process, both systems are usually involved in an interlocking manner. Through the common final stage of the two activating systems, [[prothrombin]] (Factor II) and with the cooperation of [[vitamin K]] which is formed in the liver, is converted into [[thrombin]]. The resulting thrombin is an [[enzym/en|enzyme]] that cleaves the [[fibrinogen]] (Factor I), which is also synthesized in the liver, and thus initiates the formation of [[fibrin]].
-Die Gerinnungskaskade sieht graphisch folgendermaßen aus:
+The coagulation cascade looks graphically as follows:
 [[Datei:Gerinnungskaskade_neu.png]]

@@ Zeile 30: / Zeile 30: @@
 *endogenous or intravascular pathway ([[intrinsic system]]) - in case of injury in the vessel itself, for example [[endothelial]] changes ([[inflammation]]s, [[arteriosclerosis]]), slow response
-Auf dem exogenen Weg erfolgt die Aktivierung also sehr schnell (innerhalb von Sekunden), während der Aktivierungsprozess auf dem endogenen Weg über eine größere Zahl von Zwischenstufen abläuft und längere Zeit (Minuten) benötigt. An dem normalen Gerinnungsablauf sind in der Regel beide Systeme ineinandergreifend beteiligt. Durch die gemeinsame Endstufe der beiden aktivierenden Systeme wird schließlich [[Prothrombin]] (Faktor II) und unter Mitwirkung von [[Vitamin K]] das in der Leber gebildet wird, in [[Thrombin]] umgewandelt. Das so entstandene Thrombin ist ein [[Enzym]], welches das gleichfalls in der Leber synthetisierte [[Fibrinogen]] (Faktor I) spaltet und damit die Bildung von [[Fibrin]] einleitet.
+Thus, on the exogenous pathway, activation occurs very rapidly (within seconds), whereas on the endogenous pathway, the activation process proceeds via a larger number of intermediate steps and requires a longer time (minutes). In the normal coagulation process, both systems are usually involved in an interlocking manner. Through the common final stage of the two activating systems, [[prothrombin]] (Factor II) and with the cooperation of [[vitamin K]] which is formed in the liver, is converted into [[thrombin]]. The resulting thrombin is an [[enzym/en|enzyme]] that cleaves the [[fibrinogen]] (Factor I), which is also synthesized in the liver, and thus initiates the formation of [[fibrin]].
 Die Gerinnungskaskade sieht graphisch folgendermaßen aus:

@@ Zeile 25: / Zeile 25: @@
 In this process, which normally takes 5 - 7 minutes (gerinnungszeit/en|clotting time), a '''multitude of plastic factors''' are involved in addition to platelets. Procoagulants and anticoagulants in particular work on this, with the procoagulants naturally having the upper hand in the build-up of the so-called '''secondary thrombus'''.
-=== Gerinnungskaskade ===
+=== Coagulation cascade ===
-Der eigentliche Gerinnungsprozess wird - wie die primäre Hämostase - durch die Gefäß- und Gewebsverletzung ausgelöst und auf zwei verschiedenen Wegen aktiviert:
+Like primary hemostasis, the actual coagulation process is triggered by vascular and tissue injury and activated by two different pathways:
-*exogener oder extravaskulärer Weg ([[Extrinsic-System]]) - bei Gewebsverletzungen, schnelle Reaktion
+*exogenous or extravascular pathway ([[extrinsic system]]) - in tissue injury, rapid response.
-*endogener oder intravasaler Weg ([[Intrinsic-System]]) - bei Verletzungen im Gefäß selbst, zum Beispiel [[Endothel]]veränderungen ([[Entzündung]]en, [[Arteriosklerose]]), langsame Reaktion
+*endogenous or intravascular pathway ([[intrinsic system]]) - in case of injury in the vessel itself, for example [[endothelial]] changes ([[inflammation]]s, [[arteriosclerosis]]), slow response
 Auf dem exogenen Weg erfolgt die Aktivierung also sehr schnell (innerhalb von Sekunden), während der Aktivierungsprozess auf dem endogenen Weg über eine größere Zahl von Zwischenstufen abläuft und längere Zeit (Minuten) benötigt. An dem normalen Gerinnungsablauf sind in der Regel beide Systeme ineinandergreifend beteiligt. Durch die gemeinsame Endstufe der beiden aktivierenden Systeme wird schließlich [[Prothrombin]] (Faktor II) und unter Mitwirkung von [[Vitamin K]] das in der Leber gebildet wird, in [[Thrombin]] umgewandelt. Das so entstandene Thrombin ist ein [[Enzym]], welches das gleichfalls in der Leber synthetisierte [[Fibrinogen]] (Faktor I) spaltet und damit die Bildung von [[Fibrin]] einleitet.

@@ Zeile 23: / Zeile 23: @@
 Thus, the occlusive plug now obtains its final strength only by contraction of the platelets ''"matted"'' with their pseudopodia among themselves and with the fibrin threads.
-<div class="mw-translate-fuzzy">
+In this process, which normally takes 5 - 7 minutes (gerinnungszeit/en|clotting time), a '''multitude of plastic factors''' are involved in addition to platelets. Procoagulants and anticoagulants in particular work on this, with the procoagulants naturally having the upper hand in the build-up of the so-called '''secondary thrombus'''.
 === Gerinnungskaskade ===

@@ Zeile 19: / Zeile 19: @@
 The complex coagulation system ensures that '''complete''' coagulation occurs only when it is really needed.
-<div class="mw-translate-fuzzy">
+It is activated at the site of injury at the same time that the complex platelet processes are taking place. Its much slower process ends in the formation of [[fibrin/en|fibrin]] threads that weave through the wound plug like a net and are usually also deposited in the immediate vicinity of the plug, including many [[erythrozyt/en|erythrocyte]]s.
 <div class="mw-translate-fuzzy">

@@ Zeile 16: / Zeile 16: @@
 However, this plug, the primary thrombus, is not capable of '''permanently''' closing the injured vessel site. This is a good thing, because otherwise small plugs formed too quickly could become a great danger to the circulation. This plug now slowly dissolves again, because it is only there to close smaller wounds immediately.
-<div class="mw-translate-fuzzy">
+== 3rd phase: Secondary hemostasis by clotting factors ==
-This process, which normally takes 5 - 7 minutes (coagulation time), involves platelets as well as a large number of plasmatic factors.
+The complex coagulation system ensures that '''complete''' coagulation occurs only when it is really needed.
 <div class="mw-translate-fuzzy">

@@ Zeile 13: / Zeile 13: @@
 To do this, they are activated by wall collagen fibers that extend into the area of injury. Activation means that they grow larger, that extensions develop from their wall, and that they attach themselves to the collagen fibers by means of a kind of glue. In doing so, they in turn activate other nearby platelets and thus develop a platelet plug, the so-called primary thrombus.
-<div class="mw-translate-fuzzy">
+=== Primary thrombus ===
-The final strength of the closure plug is achieved by the contraction of the platelets, which are "felted" with their pseudopodia and fibrin threads.
+However, this plug, the primary thrombus, is not capable of '''permanently''' closing the injured vessel site. This is a good thing, because otherwise small plugs formed too quickly could become a great danger to the circulation. This plug now slowly dissolves again, because it is only there to close smaller wounds immediately.
 <div class="mw-translate-fuzzy">