TNM-Einteilung/en: Unterschied zwischen den Versionen

Aktuelle Version vom 16. April 2019, 22:28 Uhr

Sprachen:

Deutsch • ‎English

The letters T-N-M are abbreviations and stand for:

T = tumour, in the sense of primary tumour;

N = Nodus lymphaticus (lymph node), in the sense of regional lymph node metastases;

M = metastasis, in the sense of haematogenic distant metastases; T = primary tumor

Tis or Cis: tumour in situ, carcinoma in situ; T1, T2, T3, T4: indicates the size of the primary tumour (T1=small, T4=large)

N = Regional lymph node metastases N0: no indication for lymph node metastases N1, N2, N3, N4: indicates the extent of regional lymph node metastasis

M = distant metastases M0: no indication for distant metastases M1: distant metastases detected

If the primary TNM formula must be changed due to later findings (surgical treatment, histological examination), this is indicated by special additives. A prefixed ″p″ means, for example, that the stadium division was carried out taking into account a pathohistological OP finding (pTNM former).

Other tumor characteristics:

Typing (cell type): histological classification of a tumor according to its original tissue. Example: adenocarcinoma. Squamous cell carcinoma, leiomyosarcoma; important for further treatment because the individual cell types respond very differently to radiation treatment or chemotherapy.

Grading (cell differentiation): The term means the degree of histological malignancy.

G1 means high differentiation (good prognosis, because highly differentiated tumors with a low degree of malignancy (in practice: bronchial carcinoids, rarely also squamous epithelial or azinic (berry-shaped) adenocarcinomas))

G2 mean differentiation, mean highly differentiated tumors with mean malignancy (in practice: mostly bronchial wall gland carcinomas, rarely also squamous epithelial or papillary adenocarcinomas)

G3 extensive de-differentiation (poor prognosis, because little differentiated tumors with high degree of malignancy (in practice: depending on staging) all advanced non-small cell lung carcinomas).

G4 'undifferentiated tumors with a very high degree of malignancy (in practice: depending on staging, all small cell lung carcinomas).

R-Classification: For the prognosis after an operation, it is decisive whether tumour remains remain in the body.

R0 resection: no residual tumor

R1-Resection: microscopic tumor residue

R2 resection: macroscopic tumor residue, infiltration depth histologically detectable depth extension. The question is now whether the primary tumor has already metastasized to the lymphatic or bloodstream (probably) in proven vascular invasions.

@@ Zeile 1: / Zeile 1: @@
 <languages />
-Die Buchstaben T-N-M sind Abkürzungen und stehen für:
+The letters T-N-M are abbreviations and stand for:
-T = Tumor, im Sinne von Primärtumor;
+T = tumour, in the sense of primary tumour;
-N = Nodus lymphaticus (Lymphknoten), im Sinne von regionären Lymphknotenmetastasen;
+N = Nodus lymphaticus (lymph node), in the sense of regional lymph node metastases;
-M = Metastase, im Sinne von hämatogenen Fernmetastasen; T = Primärtumor
+M = metastasis, in the sense of haematogenic distant metastases; T = primary tumor
-Tis oder Cis: Tumor in situ, Carcinoma in situ; T1, T2, T3, T4: gibt die Größe des Primärtumors an (T1=klein, T4=groß)
+Tis or Cis: tumour in situ, carcinoma in situ; T1, T2, T3, T4: indicates the size of the primary tumour (T1=small, T4=large)
-N = Regionäre Lymphknotenmetastasen N0: kein Anhalt für Lymphknotenmetastasen N1, N2, N3, N4: gibt das Ausmaß der regionären Lymphknotenmetastasierung an
+N = Regional lymph node metastases N0: no indication for lymph node metastases N1, N2, N3, N4: indicates the extent of regional lymph node metastasis
-M = Fernmetastasen M0: kein Anhalt für Fernmetastasen M1: Fernmetastasen nachgewiesen
+M = distant metastases M0: no indication for distant metastases M1: distant metastases detected
-Muss die primär erstellte TNM-Formel aufgrund späterer Erkenntnisse (operative Behandlung, histologische Untersuchung) geändert werden, so wird dies durch besondere Zusätze kenntlich gemacht. Ein vorangestelltes ″p″ bedeutet bspw., dass die Stadieneinteilung unter Berücksichtigung eines pathohistologischen OP-Befundes erfolgt ist (pTNM-Former).
+If the primary TNM formula must be changed due to later findings (surgical treatment, histological examination), this is indicated by special additives. A prefixed ″p″ means, for example, that the stadium division was carried out taking into account a pathohistological OP finding (pTNM former).
-Weitere Tumarcharakteristiken:
+Other tumor characteristics:
-Typing (Zelltyp): histologische Klassifikation eines Tumors nach seinem Ausgangsgewebe Bsp.: Adenokarzinom. Plattenepithelkarzinom, Leiomyosarkom; Für weitere Behandlung wichtig, weil die einzelnen Zelltypen sehr verschieden auf eine Strahlenbehandlung oder Chemotherapie ansprechen.
+Typing (cell type): histological classification of a tumor according to its original tissue. Example: adenocarcinoma. Squamous cell carcinoma, leiomyosarcoma; important for further treatment because the individual cell types respond very differently to radiation treatment or chemotherapy.
-'''Grading (Zelldifferenzierung):''' Der Begriff bezeichnet den histologischen Malignitätsgrad
+'''Grading (cell differentiation):''' The term means the degree of histological malignancy.
-G1 bedeutet hohe Differenzierung (gute Prognose, weil <u>hochdifferenzierte </u>Tumoren mit niederem Malignitätsgrad (in praxi: Bronchuskarzinoide, selten auch Plattenepithel- oder azinäre (beerenförmige) Adenokarzinome)
+G1 means high differentiation (good prognosis, because <u>highly differentiated </u>tumors with a low degree of malignancy (in practice: bronchial carcinoids, rarely also squamous epithelial or azinic (berry-shaped) adenocarcinomas))
-G2 mittlere Differenzierung,  <u>mittelhochdifferenzierte </u>Tumoren mit mittlerem Malignitätsgrad (in praxi: meist Bronchialwanddrüsenkarzinome, selten auch Plattenepithel- oder papilläre Adenokarzinome)
+G2 mean differentiation, <u>mean highly differentiated </u> tumors with mean malignancy (in practice: mostly bronchial wall gland carcinomas, rarely also squamous epithelial or papillary adenocarcinomas)
-G3 weitgehende Entdifferenzierung (schlechte Prognose, weil <u>wenig differenzierte </u>Tumoren mit hohem Malignitätsgrad (in praxi: abhängig vom Staging)  alle fortgeschrittenen nichtkleinzelligen Lungenkarzinome).''' '''
+G3 extensive de-differentiation (poor prognosis, because <u>little differentiated </u>tumors with high degree of malignancy (in practice: depending on staging) all advanced non-small cell lung carcinomas).''' '''
-G4''' '''<u>undifferenzierte </u>Tumoren mit sehr hohem Malignitätsgrad (in praxi: abhängig vom Staging alle kleinzelligen Lungenkarzinome).
+G4''' ''''<u>undifferentiated </u>tumors with a very high degree of malignancy (in practice: depending on staging, all small cell lung carcinomas).
-'''R-Klassifikation: '''Für die Prognose nach einer Op. ist entscheidend, ob Tumorreste im Körper verblieben sind.
+'''R-Classification: '''For the prognosis after an operation, it is decisive whether tumour remains remain in the body.
-R0-Resektion: kein Resttumor
+R0 resection: no residual tumor
-R1-Resektion: mikroskopischer Tumorrest
+R1-Resection: microscopic tumor residue
-R2-Resektion: makroskopischer Tumorrest, infiltrationstiefe histologisch nachweisbare Tiefenausdehnung. Die Frage ist nun, ob bei nachgewiesenen Gefäßeinbrüchen der Primärtumor bereits Metastasen auf dem Lymph- oder Blutweg gesetzt hat (wahrscheinlich).
+R2 resection: macroscopic tumor residue, infiltration depth histologically detectable depth extension. The question is now whether the primary tumor has already metastasized to the lymphatic or bloodstream (probably) in proven vascular invasions.