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The most important part in primary hemostasis is played by platelets, which are nucleated and originate from the bone marrow. We find 150'000 - 400'000 of them in the blood per microliter. The number of platelets is often increased in infectious diseases. As a result, a patient has a tendency to thrombus formation and we speak of thrombocytosis. If the platelet count decreases, a thrombocytopenia is present and this can massively disturb primary hemostasis.