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Translations:Harnsäure/2/en: Unterschied zwischen den Versionen

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Uric acid is the final product of [[purine metabolism]]. Purines are formed by the degradation of purine nucleotides (adenine and guanine) from DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). In addition, elimination also takes place via saliva and intestinal secretion. The daily excretion amounts to up to 1g. As a weak acid, uric acid is only poorly soluble in protonated form (e.g. in water), whereas it is well soluble in alkaline media. If the body is over-acidified, the uric acid is therefore less soluble. Under certain conditions there is an increased production of uric acid; if the solubility product is exceeded in the course of excretion, the uric acid can precipitate and be deposited in the urinary tract, in the bloodstream or in bradytrophic (tissue with slow metabolism) tissues. This hyperuricemia can result in uroliths, gout or uric acid infarctions.
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Uric acid is the final product of [[Purinstoffwechsel/en|purine metabolism]]. Purines are formed by the degradation of purine nucleotides (adenine and guanine) from DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). In addition, elimination also takes place via saliva and intestinal secretion. The daily excretion amounts to up to 1g. As a weak acid, uric acid is only poorly soluble in protonated form (e.g. in water), whereas it is well soluble in alkaline media. If the body is over-acidified, the uric acid is therefore less soluble. Under certain conditions there is an increased production of uric acid; if the solubility product is exceeded in the course of excretion, the uric acid can precipitate and be deposited in the urinary tract, in the bloodstream or in bradytrophic (tissue with slow metabolism) tissues. This hyperuricemia can result in uroliths, gout or uric acid infarctions.

Aktuelle Version vom 22. Mai 2019, 00:25 Uhr

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Nachricht im Original (Harnsäure)
Harnsäure ist das Endprodukt des [[Purinstoffwechsel]]s. Purine entstehen beim Abbau von Purinnukleotiden (Adenin und Guanin) aus der DNS (Deoxyribonukleinsäure) und RNS (Ribonukleinsäure). Daneben erfolgt auch eine Elimination über Speichel und intestinale Sekretion. Die tägliche Ausscheidung beträgt bis zu 1g. Harnsäure ist als schwache Säure nur schlecht in protoniertem Zustand (beispielsweise in Wasser), dagegen gut in basischen Medien löslich. Bei Übersäuerung des Körpers ist die Harnsäure also schlechter löslich. Unter bestimmten Bedingungen kommt es zu einer erhöhten Produktion von Harnsäure; wird dabei im Rahmen der Ausscheidung das Löslichkeitsprodukt überschritten, kann die Harnsäure in den ableitenden Harnwegen, in der Blutbahn oder in bradytrophen (Gewebe mit langsamem Stoffwechsel) Geweben ausfallen und abgelagert werden. Folge dieser Hyperurikämie können Urolithen, Gicht oder Harnsäureinfarkte sein.
ÜbersetzungUric acid is the final product of [[Purinstoffwechsel/en|purine metabolism]]. Purines are formed by the degradation of purine nucleotides (adenine and guanine) from DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). In addition, elimination also takes place via saliva and intestinal secretion. The daily excretion amounts to up to 1g. As a weak acid, uric acid is only poorly soluble in protonated form (e.g. in water), whereas it is well soluble in alkaline media. If the body is over-acidified, the uric acid is therefore less soluble. Under certain conditions there is an increased production of uric acid; if the solubility product is exceeded in the course of excretion, the uric acid can precipitate and be deposited in the urinary tract, in the bloodstream or in bradytrophic (tissue with slow metabolism) tissues. This hyperuricemia can result in uroliths, gout or uric acid infarctions.

Uric acid is the final product of purine metabolism. Purines are formed by the degradation of purine nucleotides (adenine and guanine) from DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). In addition, elimination also takes place via saliva and intestinal secretion. The daily excretion amounts to up to 1g. As a weak acid, uric acid is only poorly soluble in protonated form (e.g. in water), whereas it is well soluble in alkaline media. If the body is over-acidified, the uric acid is therefore less soluble. Under certain conditions there is an increased production of uric acid; if the solubility product is exceeded in the course of excretion, the uric acid can precipitate and be deposited in the urinary tract, in the bloodstream or in bradytrophic (tissue with slow metabolism) tissues. This hyperuricemia can result in uroliths, gout or uric acid infarctions.