Steroidhormone/en: Unterschied zwischen den Versionen

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5 substance families belong to the steroid hormones. In each family there are several members, the most important of which is usually called the representative.

1. estrogens: main representatives: estradiol

2. progestin; main representative: progesterone

3. androgens; main representatives: testosterone

4. mineralocorticoids; main representatives: aldosterone

5. glucocorticoids; main representatives: cortisone

What these substance families have in common is that all of them are produced from the parent substance cholesterol. Due to lipophilia in the blood, steroid hormones are bound to larger transport proteins, usually specific to the hormone in question, protecting them from rapid degradation and excretion. Since only the free hormone, not the bound hormone, is biologically active and there is a balance between the bound and free parts, the transport protein-bound hormone can also be regarded as a circulating storage form. The proportion of unbound, free hormones in lipophilic hormones is less than 5%. The plasma half-lives of this hormone group are relatively long (hours to days). The breakdown of steroid hormones occurs mainly in the liver.

Version vom 16. April 2019, 22:26 Uhr (Quelltext anzeigen) 127.0.0.1 (Diskussion) (Auto-translated text.) ← Zum vorherigen Versionsunterschied		Aktuelle Version vom 16. April 2019, 22:26 Uhr (Quelltext anzeigen) 127.0.0.1 (Diskussion) (Auto-translated text.)
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	5. glucocorticoids; main representatives: cortisone		5. glucocorticoids; main representatives: cortisone

−	~~Die Gemeinsamkeit dieser Stofffamilien besteht darin, dass alle aus der Muttersubstanz Cholesterin hergestellt werden~~. ~~Die Steroidhormone werden wegen der Lipophilie im Blut an größere~~, ~~meist für das jeweilige Hormon spezifische Transportproteine~~, ~~gebunden~~, ~~wodurch sie vor schnellem Abbau und rascher Ausscheidung geschützt werden~~. ~~Da nur das freie~~, ~~nicht das gebundene Hormon biologisch aktiv ist und ein Gleichgewicht zwischen dem gebundenen und dem freien Anteil besteht~~, ~~kann das transportproteingebundene Hormon auch als zirkulierende Speicherform angesehen werden~~. ~~Der Anteil der nicht gebundenen~~, ~~freien Hormone beträgt bei lipophilen Hormonen nur weniger als~~ 5%. ~~Die Plasmahalbwertszeiten dieser Hormongruppe sind relativ lang~~ (~~Stunden bis Tage~~). ~~Der Abbau der Steroidhormone erfolgt hauptsächlich~~ in ~~der Leber~~.	+	What these substance families have in common is that all of them are produced from the parent substance cholesterol. Due to lipophilia in the blood, steroid hormones are bound to larger transport proteins, usually specific to the hormone in question, protecting them from rapid degradation and excretion. Since only the free hormone, not the bound hormone, is biologically active and there is a balance between the bound and free parts, the transport protein-bound hormone can also be regarded as a circulating storage form. The proportion of unbound, free hormones in lipophilic hormones is less than 5%. The plasma half-lives of this hormone group are relatively long (hours to days). The breakdown of steroid hormones occurs mainly in the liver.