Glomerular Filtration Rate, (GFR)

The GFR is the filtrate volume of all glomeruli per time unit, is 125 ml/min. or 180 l/day.

The GFR depends on the total blood flow of the kidney. A high constancy of blood circulation through an autoregulation system is ensured by changes in mean blood pressure between 85 - 190 mm Hg.

It is determined diagnostically by the clearance of unrestrictedly filtered, non-reabsorbable substances in the glomerulus (e.g. inulin or creatinine).

Chronic kidney disease and GFR:

In chronic kidney disease (CKD), five stages are distinguished on the basis of GFR:

(ml/min/1.73 m²)

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