Acetylcholine

neurotransmitter of the internal uronal and neuroeffector signal transmission to acetylcholine receptors. Essential transmitter in the vegetative nervous system, especially in the parasympathetic.

Acetylcholine is on the one hand a neurotransmitter of the vegetative ganglia and on the other hand a neurotransmitter for the transmission of the nerve impulse from the efferent motor neuron to the muscle. It has a stimulating effect on the acetylcholine receptors of the downstream structures.

Clinically, descendants of the arrow poison of the Indians, the curare, are used for muscle relaxation during anaesthesia. They competitively block the acetylcholine receptors at the motor endplates. This will force all muscles to relax.

The insecticide E 605^® irreversibly inhibits the enzyme that breaks down acetylcholine. The acetylcholine can then no longer be broken down at the motor end plates, which results in an increase in the neurotransmitter concentration. This can lead to a fatal muscle spasm.

https://de.wikipedia.org/wiki/Acetylcholin _{(Wikipedia CC-by-sa-3.0)}