The ABCDE rule applies to the assessment of a malignant melanoma. The first letters of the evaluation criteria stand for
Changes in the characteristics of the skin patch indicate malignancy.
https://de.wikipedia.org/wiki/Malignes_Melanom#Assessment_according_to_the_.E2.80.9EABCDE_Rule.E2.80.9C (Wikipedia CC-by-sa-3.0)