Liver and Insulin Resistance

The liver misinterprets the insulin resistance: the resistance is a signal to the liver that there is too little glucose in the blood and it begins to form glucose from non-carbohydrate precursors.1 Insulin resistance forms a vicious circle (Circulus diaboli).1 Insulin resistance at the target tissues leads to more insulin being required to achieve euglycemia. That's why the pancreas increases insulin secretion. In this phase there is so-called compensatory hypersecretion or hyperinsulinemia.2 Too much insulin at the wrong time results in the cells reacting less to the insulin. Insulin resistance is thus further increased by the secretion disorder. Which of the two effects primarily triggers this diaboli circle still remains unclear.