(according to the publication of the German League for Combating High Blood Pressure) Drug therapy for high blood pressure should begin with monotherapy from the groups of beta-blockers, diuretics, Ca++ antagonists, alpha-blockers or ACE inhibitors. Experience has shown that in 50% of hypertensives, a normalization of the RR values can be achieved. If the effect of monotherapy is insufficient, a combination therapy should be started in the next step.